2025 -  WEEK 13

What's New in RWE Research this Week

 

  1. Effects of fetal presentation on mode of delivery in 26 143 twin pregnancies: A nationwide, population-based observational study of 31-year real-world data. Sugulle M, Laine K, Tingleff T, Murzakanova G, Räisänen S.Int J Gynaecol Obstet. 2025 Mar 29. doi: 10.1002/ijgo.70103.
  1. Association Between Rocuronium Administration and Clinical Outcomes in Patients With Moderate-To-Severe Acute Respiratory Distress Syndrome: A Retrospective Cohort Study. Tonai M, Sasabuchi Y, Watanabe H, Matsui H, Yasunaga H.Ann Pharmacother. 2025 Mar 28:10600280251329195. doi: 10.1177/10600280251329195.
  1. Artificial Intelligence in Cardiology: General Perspectives and Focus on Interventional Cardiology. Biondi-Zoccai G, D'Ascenzo F, Giordano S, Mirzoyev U, Erol Ç, Cenciarelli S, Leone P, Versaci F.Anatol J Cardiol. 2025 Apr;29(4):152-163. doi: 10.14744/AnatolJCardiol.2025.5237.PMID: 40151850 Review.
  1. Leveraging real-world data to advance biomarker discovery and precision oncology. Luo J, Solit DB.Cancer Cell. 2025 Mar 25:S1535-6108(25)00113-8. doi: 10.1016/j.ccell.2025.03.012.
  1. CLO25-056: Does Adjuvant Therapy Improve Survival Following Upfront Esophagectomy? Real World Evidence - Based on National Cancer Database Analysis. Vuthaluru S, Dougherty C, Ly QP.J Natl Compr Canc Netw. 2025 Mar 28;23(3.5):CLO25-056. doi: 10.6004/jnccn.2024.7184.
  1. Application of observational research methods to real-world studies for rare disease drugs: A scoping review protocol. Patel YP, Ghaddar L, Lin Y, Karim N, Chan K, Dupuis L, Tadrous M.PLoS One. 2025 Mar 28;20(3):e0304540. doi: 10.1371/journal.pone.0304540. eCollection 2025.PMID: 40153394 Review.
  1. Patients on treatment with risdiplam in Italy: challenges in the interpretation of the real-world data. Albamonte E, Lizio A, Coratti G, Maggi L, Pegoraro E, Pane M, Messina S, Masson R, D'Amico A, Bertini E, Pini A, Ricci F, Mongini T, Bruno C, Patanella K, Sframeli M, Dosi C, Bonanno S, Scarpini G, Brolatti N, Zanolini A, Bravetti C, Pera MC, Mercuri EM, Sansone VA; ItaSMAc.Neurol Sci. 2025 Mar 28. doi: 10.1007/s10072-025-08125-7. Online ahead of print.PMID: 40153113
  1. Second line advanced or metastatic non-small cell lung cancer treatment after chemo-immunotherapy: a retrospective study. Bazhenova L, Cai B, Gentile D, Kish J, Feinberg B.Future Oncol. 2025 Mar 28:1-8. doi: 10.1080/14796694.2025.2477975.
  1. Real-world Effectiveness of Ustekinumab Versus Anti-TNF or Vedolizumab in Ulcerative Colitis: Induction and 12-Month Maintenance Results from the Prospective, Observational RUN-UC Study. Bokemeyer B, Plachta-Danielzik S, Gilman E, Howaldt S, Mohl W, Efken P, Ehehalt R, Kahl M, Krause T, Trentmann L, Lügering A, Schnoy E, Jochum C, Hartmann P, Schreiber S.J Crohns Colitis. 2025 Mar 27:jjaf052. doi: 10.1093/ecco-jcc/jjaf052.
  1. Adverse events associated with acute pancreatitis caused by immune checkpoint inhibitors: a pharmacovigilance analysis of the FDA adverse event reporting system (FAERS) database. Tong L, Yuan Y, He W, Yang W, Pan X.Expert Opin Drug Saf. 2025 Mar 28. doi: 10.1080/14740338.2025.2486311.
  1. Serum copper to zinc ratio and risk of endometriosis: Insights from a case-control study in infertile patients. Liu Y, Cheng G, Li H, Meng Q.Reprod Med Biol. 2025 Mar 27;24(1):e12644. doi: 10.1002/rmb2.12644.
  1. Sutureless Valve Outcomes in Isolated Aortic Valve Replacement by Surgical Approach: Results from a Prospective International Real-World Registry. Concistré G, Baghai M, Santarpino G, Royse A, Scherner M, Troise G, Glauber M, Solinas M. Innovations (Phila). 2025 Mar 27:15569845251326526. doi: 10.1177/15569845251326526.
  1. A single centre experience of patients with rare cancers referred for early phase clinical trials. Angelakas A, Cook N, Graham DM, Krebs M, Thistlethwaite F, Carter L. BMC Cancer. 2025 Mar 28;25(1):558. doi: 10.1186/s12885-025-13934-2.PMID: 40148757
  1. Technology Use and Diabetes Management Across Elder Age Groups in Type 1 Diabetes and Latent Auto-Immune Diabetes of the Adult (LADA), a BETTER Registry Cross-Sectional Analysis. Wang YP, Alexandre-Heymann L, Messier V, Boudreau V, Bandini A, Kelly B, Gravel A, Gagnon C, Brazeau AS, Rabasa-Lhoret R.Endocr Pract. 2025 Mar 25:S1530-891X(25)00094-1. doi: 10.1016/j.eprac.2025.03.009.
  1. Emulating an Existing Trial of Treatments for Prostate Cancer Using Real-World Data: Challenges and lessons learned. Chesang C, Sharples LD, Gray CM, Nossiter J, van der Meulen J, Cowling TE, Keogh RH. J Clin Epidemiol. 2025 Mar 25:111767. doi: 10.1016/j.jclinepi.2025.111767.
  1. A Real-world Study on Tezepelumab Effectiveness in Severe Asthma Focusing on Small Airway Dysfunction. Menzella F, Cottini M, Lombardi C, Senna G, Chan R, Bosi A, Bortoli M, Tonin S, Corsi L, Rastelli A, Marchi MR.Respir Med. 2025 Mar 25:108054. doi: 10.1016/j.rmed.2025.108054.
  1. Explainable machine learning to identify risk factors for unplanned hospital readmissions in Nova Scotian hospitals. Maisonnave M, Rajabi E, Taghavi M, VanBerkel P.Comput Biol Med. 2025 Mar 26;190:110024. doi: 10.1016/j.compbiomed.2025.110024.
  1. Carfilzomib in relapsed/refractory multiple myeloma patients - real world evidence - experiences of the Croatian cooperative group for hematologic diseases (KROHEM). Galusic D, Batinic J, Krecak I, Dreta B, Radic Kristo D, Pirsic M, Rincic G, Sincic-Petricevic J, Valkovic T, Vujcic M, Simunic M, Misura Jakobac K, Sedinic Lacko M, Brcic K, Perisa V, Petricevic F, Grohovac D, Holik H, Moric Peric M, Zekanovic I, Bernes P, Kuzat L, Romic I, Zupanic Krmek D, Basic-Kinda S.Cancer Treat Res Commun. 2025 Mar 24;43:100912. doi: 10.1016/j.ctarc.2025.100912.
  1. Large Language Model-Driven Knowledge Graph Construction in Sepsis Care Using Multicenter Clinical Databases: Development and Usability Study. Yang H, Li J, Zhang C, Sierra AP, Shen B.J Med Internet Res. 2025 Mar 27;27:e65537. doi: 10.2196/65537.PMID: 40146985 
  1. Once-Weekly Semaglutide Versus Sodium-Glucose Co-transporter 2 Inhibitors: Real-World Impact on Weight, HbA1c, and Healthcare Resource Utilization in Type 2 Diabetes (PAUSE). Amamoo J, Doshi R, Noone J, Xie L, Gamble C, Guevarra M, Divino V, Chen J, King A. Diabetes Ther. 2025 Mar 27. doi: 10.1007/s13300-025-01721-y. Online ahead of print.PMID: 40146378
  1. Real-WorldData Analysis of Genomic Alterations Detected by a Dual DNA-RNA Comprehensive Genomic Profiling Test. Watanabe K, Ogawa M, Shinozaki-Ushiku A, Tsutsumi S, Tatsuno K, Aburatani H, Kage H, Oda K.Cancer Sci. 2025 Mar 26. doi: 10.1111/cas.70071.
  1. A SuperLearner approach for predicting diabetic kidney disease upon the initial diagnosis of T2DM in hospital. Lin X, Liu C, Wang H, Fan X, Li L, Xu J, Li C, Wang Y, Cai X, Peng X. BMC Med Inform Decis Mak. 2025 Mar 26;25(1):148. doi: 10.1186/s12911-025-02977-x.PMID: 40140809 
  1. Precision Oncology Program (POP), an observational study using real-world data and imaging mass cytometry to explore decision support for the Molecular Tumor Board: study protocol. Boos LA, Doerig C, Gut G, Miglino N, Fábregas Ibáñez L, Rizzo S, Schärfe Fruechtenicht C, Chitale N, Lu C, Zoche M, Bodenmiller B, Chevrier S, Eklund AS, Nowak M, Rahmani Khajouei S, Berardo CG, Kaczmarek L, Bosshard K, Archey W, Bodmer M, Glinz D, Camarillo-Retamosa E, Hempel CL, Rahimzadeh P, Gosztonyi B, Richter U, Bankel L, Wicki A.BMJ Open. 2025 Mar 26;15(3):e096591. doi: 10.1136/bmjopen-2024-096591.PMID: 40139698 
  1. RE: Comprehensive genome profiling for treatment decisions in patients with metastatic tumors: real-world evidence meta-analysis and registry data implementation. Yuan J, Yu J. J Natl Cancer Inst. 2025 Mar 26:djaf079. doi: 10.1093/jnci/djaf079.
  1. Five-year Results of Aortic Valve Replacement with a Novel Bioprosthesis: Real-world data from a large multicenter registry. Onorati F, Geisler D, Theron A, Francica A, Caruso V, Mariani C, Fiore A, Hegeman R, Porto A, Folliguet T, Lucchese G, Klein P, Pacini D, Grabenwöger M, Luciani GB.Ann Thorac Surg. 2025 Mar 24:S0003-4975(25)00225-5. doi: 10.1016/j.athoracsur.2025.03.015.
  1. One-year outcomes after switching to faricimab in eyes with pre-treated neovascular age-related macular degeneration: a Swiss Retina Research Network report. Grimaldi G, Ambresin A, Pfister IB, Schild C, Plasencia C, Hatz K, Stillenmunkes R, Munk MR, Paris A, Menghini M, Artemiev D, Ebneter A, Cattaneo J, de Oliveira Figueiredo EC, Eandi CM, Fröhlich J, Feltgen N, Spitznagel T, Somfai GM, Cozzi M, Zweifel S, Weinberger A, Garweg JG. Ophthalmol Retina. 2025 Mar 24:S2468-6530(25)00124-1. doi: 10.1016/j.oret.2025.03.015.
  1. Pharmacogenomic heterogeneity of N-acetyltransferase 2: a comprehensive analysis of real world data in Indian tuberculosis patients and from literature and database review. Thomas L, Chaithra, Batra Y, Mathur M, Kulavalli S, Sv CS, Dutt N, Bhardwaj P, Varma M, Saravu K, Banerjee M, Rao M.Ann Med. 2025 Dec;57(1):2478316. doi: 10.1080/07853890.2025.2478316.
  1. Targeted and regional biopsy in prostate cancer: first real-world data. Long-Depaquit T, Corral R, Uleri A, Peyrottes A, Campagna J, Toledano H, Bastide C, Baboudjian M.World J Urol. 2025 Mar 26;43(1):187. doi: 10.1007/s00345-025-05585-6.PMID: 40138013
  1. Epidemiology with real-world data: deep endometriosis in women of reproductive age. Szylit NA, Raiza LCP, Leal AAS, Podgaec S.Einstein (Sao Paulo). 2025 Mar 24;23:eAO1259. doi: 10.31744/einstein_journal/2025AO1259. eCollection 2025.PMID: 40136149 
  1. Predicting high anger intensity using ecological momentary assessment and wearable-derived physiological data in a trauma-affected sample. Metcalf O, Lamb KE, Forbes D, O'Donnell ML, Qian T, Varker T, Cowlishaw S, Zaloumis S.Eur J Psychotraumatol. 2025 Dec;16(1):2472485. doi: 10.1080/20008066.2025.2472485.
  1. Calibration of transition probabilities to model survival of adjuvant trastuzumab for early breast cancer in Indonesia. Rahadi A, Mahardya RTK, Listiani P, Herlinawaty E, Nugraha RR, Budiman DR, Suharlim C.Int J Technol Assess Health Care. 2025 Mar 26;41(1):e18. doi: 10.1017/S0266462325000157.PMID: 40135279
  1. Contemporary real-world treatment in metastatic hormone-sensitive prostate cancer: US, four European countries, and UK. Goebell PJ, Chen S, Jhaveri J.Future Oncol. 2025 Mar 26:1-14. doi: 10.1080/14796694.2025.2481024.
  1. Efficacy of treatment with faricimab for patients with refractory nAMD. Jones N, Gore C, Saedon H, O'Donnell C, Mahmood S. Eur J Ophthalmol. 2025 Mar 26:11206721251328097. doi: 10.1177/11206721251328097. Online ahead of print.PMID: 40134284
  1. Real-world data of polatuzumab vedotin with bendamustine and rituximab for Japanese relapsed and refractory DLBCL: a multicenter retrospective study. Fujino T, Okamoto H, Nishiyama D, Hayata H, Sasaki N, Kobayashi T, Maekura C, Kuwahara-Ota S, Takimoto-Shimomura T, Shimura K, Kawaji-Kanayama Y, Inoue Y, Chinen S, Isa R, Tsukamoto T, Mizutani S, Shimura Y, Kaneko H, Nakao M, Fuchida S, Takahashi R, Uchiyama H, Uoshima N, Kuroda J; Kyoto Clinical Hematology Study Group.Leuk Lymphoma. 2025 Mar 25:1-12. doi: 10.1080/10428194.2025.2483390.
  1. Impact of SGLT2 inhibitors on survival in gastrointestinal cancer patients undergoing chemotherapy and/or radiotherapy: a real-world data retrospective cohort study. Flausino LE, Carrasco AGM, Furuya TK, Tuan WJ, Chammas R.BMC Cancer. 2025 Mar 25;25(1):542. doi: 10.1186/s12885-025-13966-8.PMID: 40133838 
  1. Deep-Learning-Assisted Analysis of Early Biomarker Changes in Treatment-Naïve Patients with Neovascular AMD Under Intravitreal Faricimab.
  2. Hafner M, Asani B, Eckardt F, Siedlecki J, Schworm B, Priglinger SG, Schiefelbein J.Ophthalmol Ther. 2025 Mar 25. doi: 10.1007/s40123-025-01125-y.
  1. Assessing the accuracy of the GPT-4 model in multidisciplinary tumor board decision prediction. Erdat EC, Yalçıner M, Örüncü MB, Ürün Y, Şenler FÇ. Clin Transl Oncol. 2025 Mar 25. doi: 10.1007/s12094-025-03905-1. Online ahead of print.PMID: 40133589
  1. Detection of Clinically Significant Drug-Drug Interactions in Fatal Torsades de Pointes: Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System. Ji H, Gong M, Gong L, Zhang N, Zhou R, Deng D, Yang Y, Song L, Jia Y.J Med Internet Res. 2025 Mar 25;27:e65872. doi: 10.2196/65872.PMID: 40132181 
  1. Comparative real-world effectiveness of ustekinumab versus anti-TNF in Crohn's disease: 12-month maintenance phase results from the prospective, observational RUN-CD study using propensity score adjustment. Bokemeyer B, Plachta-Danielzik S, Gilman E, di Giuseppe R, Deppe H, Mohl W, Teich N, Hoffstadt M, Schweitzer A, von der Ohe M, Gauss A, Atreya R, Krause T, Blumenstein I, Hartmann P, Schreiber S.J Crohns Colitis. 2025 Mar 25:jjaf051. doi: 10.1093/ecco-jcc/jjaf051.
  1. Treatment patterns and outcomes in HER2-low metastatic breast cancer patients previously treated with chemotherapy: a US real-world cohort study. Modi S, Zhang S, Byng D, Hunter S, Strübing A, Xiong Y, Dunton K, Mbanya Z, Jacot W.Breast Cancer Res Treat. 2025 Mar 25. doi: 10.1007/s10549-025-07649-y. Online ahead of print.PMID: 40131662
  1. Real-World Data on Alcohol Consumption Behavior Among Smartphone Health Care App Users in Japan: Retrospective Study. Eguchi K, Kubota T, Koyanagi T, Muto M.Online J Public Health Inform. 2025 Mar 25;17:e57084. doi: 10.2196/57084.PMID: 40131328 
  1. Tyrosine kinase inhibitor discontinuation and reinitiation patterns in CML patients in the US: real-world evidence. Sarker J, Atallah EL, Flynn KE, Winn AN.Leuk Lymphoma. 2025 Mar 25:1-6. doi: 10.1080/10428194.2025.2482133.
  1. The cost of emulated target trials: Is real-world data cheaper than randomized studies? Barosa M, Prasad V.Eur J Clin Invest. 2025 Mar 25:e70035. doi: 10.1111/eci.70035. Online ahead of print.PMID: 40130313 No abstract available.
  1. Levodopa-Entacapone-Carbidopa Intrajejunal Infusion in Advanced Parkinson's Disease - Interim Analysis of the ELEGANCE Study. Weiss D, Jost WH, Szász JA, Pirtošek Z, Milanov I, Tomantschger V, Kovács N, Staines H, Amlani B, Smith N, van Laar T.Mov Disord Clin Pract. 2025 Mar 25. doi: 10.1002/mdc3.70046. Online ahead of print.PMID: 40129359
  1. Pharmacokinetics of post-transplant cyclophosphamide and its associations with clinical outcomes in pediatric haploidentical hematopoietic stem cell transplantation. Hong KT, Bae S, Sunwoo Y, Lee J, Park HJ, Kim BK, Choi JY, Cho JY, Yu KS, Oh J, Kang HJ.Biomark Res. 2025 Mar 24;13(1):48. doi: 10.1186/s40364-025-00749-3. PMID: 40128919 
  1. SCANIA Component X dataset: a real-world multivariate time series dataset for predictive maintenance. Kharazian Z, Lindgren T, Magnússon S, Steinert O, Andersson Reyna O.Sci Data. 2025 Mar 24;12(1):493. doi: 10.1038/s41597-025-04802-6.PMID: 40128259 
  1. Gout incidence in metformin versus sodium-glucose co-transporter-2 inhibitor users: a retrospective cohort study. Hatano M, Okada A, Sasabuchi Y, Ishikura H, Tanaka T, Saito T, Tanaka S, Yasunaga H.Rheumatology (Oxford). 2025 Mar 24:keaf136. doi: 10.1093/rheumatology/keaf136.
  1. Multidimensional assessment of adverse events of finasteride：a real-world pharmacovigilance analysis based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024. Zhong X, Yang Y, Wei S, Liu Y.PLoS One. 2025 Mar 24;20(3):e0309849. doi: 10.1371/journal.pone.0309849. eCollection 2025.PMID: 40127098 
  1. Emerging molecular testing paradigms in non-small cell lung cancer management-current perspectives and recommendations. Penault-Llorca F, Socinski MA. 2025 Mar 24:oyae357. doi: 10.1093/oncolo/oyae357.
  1. Patient and Public involvement and engagement in real world data and evidence research across the medicines development cycle: a rapid review of peer-reviewed literature and NICE technology appraisals. Dews SA, Oluwatomi A, Inskip A, Agbeleye O, Markham S, Latchford P, Bohm N, Westergaard P, Butfield R, Campbell-Burton A, Meader N, Stoniute A.Curr Med Res Opin. 2025 Mar 24:1-17. doi: 10.1080/03007995.2025.2482668.
  1. Incidence of the Stevens-Johnson syndrome spectrum and its patterns in urban China. Li C, Dai M, Gu Q, Lu K, Ge C, Liu X, Li Z, Wang J, Wang J, Wei C, Tang X, Zheng Q, Gao P, Chen W.J Dermatol. 2025 Mar 24. doi: 10.1111/1346-8138.17692.
  1. Surgery for benign prostate enlargement in England: 10-year retrospective study of 155 874 patients. Page T, O'Toole E, Keltie K, Abdelmotagly Y, Richardson H, Parker R, Sims AJ.BJU Int. 2025 Mar 24. doi: 10.1111/bju.16713. Online ahead of print.PMID: 40123518
  1. Proceedings from The Consortium for Technology & Innovation in Pediatrics (CTIP) 2024 Annual Pediatric Device Innovation Symposium. Lambert TP, Zapotoczny G, Riello B, Afari N, Bar-Cohen Y, Christmas M, Jamal S, Qazi S, Bent MA, Espinoza J.BMC Proc. 2025 Mar 24;19(Suppl 3):8. doi: 10.1186/s12919-025-00315-7.PMID: 40122812 
  1. Outcomes of Virtual Pulmonary Rehabilitation in Oxygen-Dependent COPD Patients. Filizola H, Kumar A, Buhr RG, Schwab Jensen K. Chronic Obstr Pulm Dis. 2025 Mar 27;12(2):184-189. doi: 10.15326/jcopdf.2024.0572.PMID: 40037281 
  1. Disease Onset and Burden in Patients With Chronic Bronchitis and COPD: A Real-World Evidence Krishnan JK, Criner GJ, Lashari BH, Martinez FJ, Kim V, Lindoulsi A, Khokhlovich E, Altman P, Karcher H, Schoenberger M.Chronic Obstr Pulm Dis. 2025 Mar 27;12(2):127-136. doi: 10.15326/jcopdf.2024.0565.PMID: 40037280 
  1. Implementation of Medication-Related Technology and Its Impact on Pharmacy Workflow: Real-World Evidence Usability Study. Yu WN, Cheng YD, Hou YC, Hsieh YW.J Med Internet Res. 2025 Mar 27;27:e59220. doi: 10.2196/59220.PMID: 40019479 
  1. Real-world effectiveness and tolerability of sotorasib in patients with KRAS G12C-mutated metastatic non-small cell lung cancer: The IFCT-2102 Lung KG12Ci study. Wislez M, Mascaux C, Cadranel J, Thomas QD, Ricordel C, Swalduz A, Pichon E, Veillon R, Gounant V, Rousseau-Bussac G, Madroszyk A, Daniel C, Ravoire M, Metivier AC, Fournel P, Missy P, Morin F, Guisier F, Westeel V.Eur J Cancer. 2025 Mar 26;219:115301. doi: 10.1016/j.ejca.2025.115301.
  1. Challenges and opportunities for hepatitis B virus screening in people attending PrEP services: a retrospective prevalence study. Monti B, Rossotti R, D'Aloia F, Calzavara D, Corsico L, Cernuschi M, Puoti M, Bonfanti P, Soria A.Sex Transm Infect. 2025 Mar 24;101(2):121-124. doi: 10.1136/sextrans-2024-056245.PMID: 39401904