2025 -  WEEK 9 - What's New in RWE Research

 

  1. Short- and long-term comparative effectiveness of nirmatrelvir/ritonavir and molnupiravir in asthma patients: a cohort study. Lin G, Wei Y, Guo Z, Wang H, Chan KCC, Chan RWY, Hung CT, Jiang X, Li C, Yam CHK, Chow TY, Wang Y, Zhao S, Li K, Yang A, Mok CKP, Hui DSC, Yeoh EK, Chong KC.Respir Res. 2025 Feb 28;26(1):75.

 

  1. Evaluating the uptake of a Global Initiative for Asthma guideline update in a commercially insured, value-based care population. McInturff LM, Smith S.J Manag Care Spec Pharm. 2025 Mar;31(3):245-252.

 

  1. Analysis of national real-world data on reoperations after medial unicompartmental knee arthroplasty : insights from a high-usage country. Bredgaard Jensen C, Lindberg-Larsen M, Kappel A, Henkel C, Mark-Christensen T, Gromov K, Troelsen A. Bone Joint J. 2025 Mar 1;107-B(3):314-321.

 

  1. The EU project Real4Reg: unlocking real-world data with AI. Peltner J, Becker C, Wicherski J, Wortberg S, Aborageh M, Costa I, Ehrenstein V, Fernandes J, Heß S, Horváth-Puhó E, Korcinska Handest MR, Lentzen M, Maguire P, Meedom NH, Moore R, Moore V, Nagy D, McNamara H, Paakinaho A, Pfeifer K, Pylkkänen L, Rajamaki B, Reviers E, Röthlein C, Russek M, Silva C, De Valck D, Vo T, Bräuner E, Fröhlich H, Furtado C, Hartikainen S, Kallio A, Tolppanen AM, Haenisch B. Health Res Policy Syst. 2025 Feb 27;23(1):27.

 

  1. Patients with obstructive sleep apnea in Germany. Winter Y, Mayer G, Benes H, Burghaus L, Floam S, Parks GS, Kallweit U.Sleep Breath. 2025 Feb 27;29(1):112. doi: 10.1007/s11325-025-03275-6.PMID: 40014191

 

  1. Burden of illness among patients with asthma prescribed inhaled corticosteroids/long-acting β2-agonists. Zhang S, Czira A, Harley J, Rothnie KJ, Lee L, Small M.NPJ Prim Care Respir Med. 2025 Feb 26;35(1):10.

 

  1. Risk of Pneumocystis jiroveciiPneumonia in Patients With HIV in Taiwan: Evidence from a Cross-sectional Study. Wang JY, Huang KH, Tai CJ, Gau SY, Tsai TH, Wu CN, Lee CY. In Vivo. 2025 Mar-Apr;39(2):1054-1066.

 

  1. Understanding the quality of ethnicity data recorded in health-related administrative data sources compared with Census 2021 in England. Razieh C, Powell B, Drummond R, Ward IL, Morgan J, Glickman M, White C, Zaccardi F, Hope J, Raleigh V, Akbari A, Islam N, Yates T, Murphy L, Mateen BA, Khunti K, Nafilyan V.PLoS Med. 2025 Feb 26;22(2):e1004507.

 

  1. Autoimmune disease and risk of lymphoma: analysis from real-world data and Mendelian randomization study. Zhan L, Chen S, Liu Y, Lu T, Yu Z, Wang X, Zhou X.BMC Cancer. 2025 Feb 25;25(1):351.

 

  1. Conducting a real-world study of Tumor Necrosis factor-alpha inhibitors-induced Systemic Lupus Erythematosus based on the FAERS database. He M, Yang J, Yan S, Shu Q, Liu PC. Sci Rep. 2025 Feb 26;15(1):6838.

 

  1. Monitoring peripheral blood data supports the prediction of immunotherapy response in advanced non-small cell lung cancer based on real-world data. Ramos-Guerra AD, Farina B, Rubio Pérez J, Vilalta-Lacarra A, Zugazagoitia J, Peces-Barba G, Seijo LM, Paz-Ares L, Gil-Bazo I, Dómine Gómez M, Ledesma-Carbayo MJ. Cancer Immunol Immunother. 2025 Feb 25;74(4):120.

 

  1. An integrated prognosis prediction model based on real-word clinical characteristics for immunotherapy in advanced esophageal squamous cell carcinoma. Dong L, Ma Y, Cao G, Chen D, Dong F, Jiao X, Cao Y, Liu C, Wang Y, Zhuo N, Wang F, Guo Y, Dai T, Zhang S, Jiao H, Zou X, Li J, Shen L, He Z, Zhang Y, Lu Z.Cancer Immunol Immunother. 2025 Feb 25;74(4):112.

 

  1. Treatments and Outcomes of Newly Diagnosed CD5-Positive Diffuse Large B-Cell Lymphoma: A Multi-Institutional Observational Study. Nato Y, Miyazaki K, Maruyama D, Takahashi H, Sunami K, Murakami S, Negoro E, Miyazawa Y, Choi I, Okada T, Takayama N, Tomita N, Momose S, Kaneda Y, Yoshida M, Gomyo H, Toyama K, Nishikori M, Saito A, Hiraga J, Masunari T, Takahashi N, Makiyama J, Suzuki T, Tsunemine H, Takizawa J, Kato T, Masaki Y, Fukuhara N, Okamoto M, Tawara I, Asano N, Ohshima K, Izutsu K, Kato K, Suzuki R, Yamaguchi M.Hematol Oncol. 2025 Mar;43(2):e70047.

 

  1. Treatment with nintedanib is as effective and safe in patients with other connective tissue diseases (CTDs)-interstitial lung disease (ILD) as in patients with systemic sclerosis-ILD: A multicenter retrospective study. Mısırcı S, Ekin A, Yağız B, Coşkun BN, Başıbüyük F, Birlik AM, Sarı İ, Karaca AD, Koca SS, Yıldırım Çetin G, Okyar B, Atilla N, Dalkılıç E, Pehlivan Y.Clin Rheumatol. 2025 Mar;44(3):1187-1195.

 

  1. Towards real-world clinical data standardization: A modular FHIR-driven transformation pipeline to enhance semantic interoperability in healthcare. Marfoglia A, Nardini F, Arcobelli VA, Moscato S, Mellone S, Carbonaro A. Comput Biol Med. 2025 Mar;187:109745.

 

  1. Are we giving too much oxygen to patients at risk of hypercapnia? Real world data from a large teaching hospital. O'Driscoll BR, Bakerly ND.Respir Med. 2025 Mar;238:107965.

 

  1. Redefining vitamin D status: Establishing population-based indirect reference intervals through big data analysis. Fabregat-Bolufer AB, Escolà-Rodríguez A, Bedini-Chesa JL, Casals G, Morales-Ruiz M, Filella X.Clin Chim Acta. 2025 Mar 1;569:120155.

 

  1. Early Corticosteroid Use and Short-Term Outcomes in Pediatric Bacterial Meningitis: A Nationwide Study in Japan, 2014 to 2022. Kameda S, Yamana H, Sasabuchi Y, Michihata N, Aso S, Matsui H, Fushimi K, Yasunaga H, Kohro T.Pediatr Neurol. 2025 Mar;164:97-104.

 

  1. Survival improvements in patients with melanoma brain metastases and leptomeningeal disease in the modern era: Insights from a nationwide study (2015-2022). Pedersen S, Johansen EL, Højholt KL, Pedersen MW, Mogensen AM, Petersen SK, Haslund CA, Donia M, Schmidt H, Bastholt L, Friis R, Svane IM, Ellebaek E.Eur J Cancer. 2025 Feb 25;217:115253.

 

  1. A 5-Year Single-center Experience on the Use of Emicizumab Prophylaxis in Children With Severe Hemophilia A With and Without Factor VIII Inhibitors. Ahmed Hasan EM, Motwani J. J Pediatr Hematol Oncol. 2025 Mar 1;47(2):e83-e89.

 

  1. Real-world evidence of yellow Fever vaccination data-driven study. Farnsworth MG, Khanipov K, Botnar K, Weaver SC, Barrett ADT, Golovko G. 2025 Feb 27;48:126758.

 

  1. Validating the accuracy of mathematical model-based pharmacogenomics dose prediction with real-world data. Saab Y, Nakad Z.Eur J Clin Pharmacol. 2025 Mar;81(3):451-462.

 

  1. Guideline-directed medical therapy for heart failure: Real-world evidencein one Latin-American center. Jiménez JM, Restrepo LJ, Villa M, Gutiérrez S, Villarreal I, Vanegas JM, Díaz-Betancur JS.Curr Probl Cardiol. 2025 Mar;50(3):102990.

 

  1. Real-world evidence in extensive disease small cell lung cancer: The missing piece of the puzzle. Damiano P, Stefani A, Avancini A, Belluomini L, Bria E, Pilotto S.Crit Rev Oncol Hematol. 2025 Mar;207:104618. Review.

 

  1. RET-AREAL: A multi-center, real-world data analysis on the efficacy of pralsetinib in acquired RET fusion after resistance to EGFR/ALK-TKIs. Tang X, Hu J, Guo R, Wang Y, Yao Y, Zeng L, Wang H, Shen H, Chen J, Huang W, Liu L, Su M, Yu Z, Mao W, Wang J, Tao H, Dong G, Cai C, Xie Y, Qu T, Zhang Y, Shen W, Cao J, Cai X, Kong W, Li X, Liang F.Cancer Lett. 2025 Mar 1;612:217455.

 

  1. Objective study validity diagnostics: a framework requiring pre-specified, empirical verification to increase trust in the reliability of real-world evidence. Conover MM, Ryan PB, Chen Y, Suchard MA, Hripcsak G, Schuemie MJ. J Am Med Inform Assoc. 2025 Mar 1;32(3):518-525.

 

  1. Weight loss and body composition after compounded semaglutide treatment in a real world setting. Chun E, Siojo A, Rivera D, Reyna K, Legere H, Joseph R, Pojednic R.Diabetes Obes Metab. 2025 Mar;27(3):1536-1543.

 

  1. The real-world efficacy and safety of frontline therapy of obinutuzumab plus bendamustine for untreated high-tumor-burden follicular lymphoma. Nagata H, Tsukamoto T, Kobayashi T, Takahashi R, Okano A, Uchiyama H, Kawata E, Uoshima N, Kaneko H, Fuchida SI, Nishiyama D, Nakao M, Fujino T, Mizutani S, Shimura Y, Kuroda J. Int J Clin Oncol. 2025 Mar;30(3):593-603.

 

  1. Prevalence of urinary tract infections in women with vulvovaginal atrophy and the impact of vaginal prasterone on the rate of urinary tract infections. Rubin R, Sanaee M, Yee A, Moyneur E, Dea K, Dury AY. 2025 Mar 1;32(3):217-227.

 

  1. Treatment outcomes with oral anti-hyperglycaemic therapies in people with diabetes secondary to a pancreatic condition (type 3c diabetes): A population-based cohort study. Hopkins R, Young KG, Thomas NJ, Jones AG, Hattersley AT, Shields BM, Dennis JM, McGovern AP; MASTERMIND consortium. Diabetes Obes Metab. 2025 Mar;27(3):1544-1553.

 

  1. Real-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma. Jutten E, van Kempen LCLT, Diercks GFH, van Leeuwen BL, Kruijff S, Wevers KP.Mol Diagn Ther. 2025 Mar;29(2):229-238.

 

  1. Sex-Based Differences of Thoracic Endovascular Aortic Repair for Stanford Type B Aortic Dissections. Moacdieh MP, Zarrintan S, Janssen CB, Yei KS, Patel RJ, Gaffey AC, Malas MB.Ann Vasc Surg. 2025 Mar;112:344-351.

 

  1. Enhancing patient representation learning with inferred family pedigrees improves disease risk prediction. Huang X, Arora J, Erzurumluoglu AM, Stanhope SA, Lam D; Boehringer Ingelheim—Global Computational Biology and Digital Sciences; Zhao H, Ding Z, Wang Z, de Jong J. J Am Med Inform Assoc. 2025 Mar 1;32(3):435-446.

 

  1. Modeling the fasting blood glucose response to basal insulin adjustment in type 2 diabetes: An explainable machine learning approach on real-world data. Thomsen CHN, Kronborg T, Hangaard S, Vestergaard P, Hejlesen O, Jensen MH. Int J Med Inform. 2025 Mar;195:105758.

 

  1. TP53 Mutation Is the Only Robust Mutational Biomarker for Outcome Found in a Consecutive Clinical Cohort of Real-Word Patients With Primary Large B-Cell Lymphoma. Breinholt MF, Schejbel L, Gang AO, Christensen IJ, Nielsen TH, Pedersen LM, Høgdall E, Nørgaard P. Eur J Haematol. 2025 Mar;114(3):573-579.

 

  1. Addressing the challenges of integrating digital health technologies to measure patient-centred outcomes in clinical registries. Marra C, Chico T, Alexandrow A, Dixon WG, Briffa N, Rainaldi E, Little MA, Size K, Tsanas A, Franklin JB, Kapur R, Grice H, Gariban A, Ellery J, Sudlow C, Abernethy AP, Morris A. Lancet Digit Health. 2025 Mar;7(3):e225-e231.

 

  1. Effect of single-pill versus free equivalent combinations on persistence and major adverse cardiovascular events in hypertension: a real-world analysis. Simonyi G, Burnier M, Narkiewicz K, Rokszin G, Abonyi-Tóth Z, Kovács G, Potukuchi PK, Abdel-Moneim M, Farsang C.J Hypertens. 2025 Mar 1;43(3):405-412.

 

  1. Talquetamab in Multiple Myeloma: Efficacy, Safety, and Future Directions. Labanca C, Martino EA, Vigna E, Bruzzese A, Mendicino F, Lucia E, Olivito V, Puccio N, Neri A, Morabito F, Gentile M.Eur J Haematol. 2025 Mar;114(3):386-399.

 

  1. NSW cannabis medicines advisory service retrospective enquiry analysis to inform clinical guidance resource development. Graham M, Eden E, Maddison K, Lago L, Allingham S, Lucas CJ, Schneider J, Martin JH.Neuropsychopharmacol Rep. 2025 Mar;45(1):e12498.

 

  1. Real-world use of androgen-deprivation therapy intensification for metastatic hormone-sensitive prostate cancer: a systematic review. Raval AD, Chen S, Littleton N, Constantinovici N, Goebell PJ.BJU Int. 2025 Mar;135(3):408-421.

 

  1. Lenalidomide in Transfusion-Dependent IPSS Low- or Intermediate-1-Risk Myelodysplastic Syndromes and Isolated Del(5q): Results of a European Postauthorization Safety Surveillance Study. Poloni A, Raaschou-Jensen K, Mohedo FH, Paolini S, Oliva EN, Buccisano F, Vasconcelos A, Kim I, Makwana A, Bernasconi D, Rosettani B, Prebet T, Santini V.Clin Lymphoma Myeloma Leuk. 2025 Mar;25(3):e131-e142.

 

  1. Using Real-World Data to Assess the Association of Retinal Detachment With Topical Pilocarpine Use.Elhusseiny AM, Chauhan MZ, Jabbehdari S, Alshammari N, Jong S, Phillips PH, Sallam AB.Am J Ophthalmol. 2025 Mar;271:1-6.

 

  1. Nivolumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: Results of Polish multicenter observational study. Rutkowski TW, Kurczyk A, Drosik-Rutowicz K, Kiprian D, Dębicka I, Sierko E, Konopka-Filippow M, Kaźmierska J, Łukasiewicz-Grella M, Cząstkiewicz-Trawińska D, Mrochem-Domin I, Ryniewicz-Zander I, Borysiewicz Z, Chmielowska E, Jasiówka M, Źrebiec-Figura M, Karpińska A, Pacholczak-Madej R, Leś D, Pietruszka A, Łasinska I, Składowski K.Int J Cancer. 2025 Mar 1;156(5):1074-1084.

 

  1. A real-world evidence study of interhospital variability in the surgical treatment of patients with benign prostatic hyperplasia: the REVALURO study. Iván PM, Alberto BA, Lluís PC, Maurizio D, Jose Luís GB, Francisco Javier VP, Almudena SB, Jaime GH, Esperanza TM, Pablo BA, Gabriela OA, Manuel GB, Miguel Ángel C, Alberto CG, Emilio LA.Int Urol Nephrol. 2025 Mar;57(3):775-784.

 

  1. Real-world evidence of lisinopril in pediatric hypertension and nephroprotective management: a 10-year cohort study. Degraeuwe E, Gasthuys E, Snauwaert E, Dossche L, Prytula A, Dehoorne J, Vermeulen A, Walle JV, Raes A. Pediatr Nephrol. 2025 Mar;40(3):797-809.

 

  1. Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS. Cluzeau T, Guolo F, Chiche E, Minetto P, Rahme R, Bertoli S, Fianchi L, Micol JB, Gottardi M, Peterlin P, Galimberti S, Thomas X, Rizzuto G, Legrand O, Rondoni M, Raffoux E, Bertani G, Caulier A, D'Argenio M, Bonmati C, Billio A, Lejeune C, Scappini B, Pigneux A, Zappasodi P, Recher C, Grimaldi F, Ades L, Lemoli RM. Blood Adv. 2025 Feb 25;9(4):752-758.

 

  1. Preoperative risk-factors for secondary spontaneous pneumothorax surgery in Japan: a nationwide database study. Waseda R, Yamamoto H, Shintani Y, Sato T, Suzuki K, Maniwa Y, Sato Y, Yoshino I, Chida M.Surg Today. 2025 Mar;55(3):393-404.

 

  1. Intereye Asymmetry as a Predictor of Progression in Patients With Untreated Keratoconus: Findings From a Longitudinal Study. Arnalich-Montiel F, Ortiz-Toquero S, Kandel H, Lewis N, Chiong Hong S, Downie N, Watson A, Abbondanza M, Watson S. 2025 Mar 1;44(3):337-341.

 

  1. Prospective, comparative, pilot study of maintenance treatment in comorbid bipolar disorders with post-traumatic stress disorder. Guillen-Burgos HF, Gálvez-Flórez JF, Moreno-Lopez S, Kwan ATH, McIntyre RS.Int Clin Psychopharmacol. 2025 Mar 1;40(2):75-83.